Paraneoplastic neurologic syndrome and autoantibody accompaniments of germ cell tumors.
Handb Clin Neurol
; 200: 431-445, 2024.
Article
em En
| MEDLINE
| ID: mdl-38494295
ABSTRACT
Paraneoplastic neurologic syndromes (PNSs) are a group of diseases affecting the central and/or peripheral nervous system caused by immune-mediated processes directed toward antigens with shared expression in tumor and neural tissue. Germ cell tumors (GCTs) are associated with PNSs with varied clinical phenotypes. Early diagnosis of PNS is vital to potentially uncover and treat underlying tumors, improving the chances of recovery, and preventing permanent neurologic complications. In this chapter, we outline the pathophysiology and epidemiology of PNS. We briefly provide a summary of GCTs in males and females. We review the neural-specific autoantibodies and PNSs associated with GCTs and their clinical and radiologic accompaniments. We also provide an overview of the treatment and prognosis of these disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Embrionárias de Células Germinativas
/
Síndromes Paraneoplásicas do Sistema Nervoso
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Doenças do Sistema Nervoso
Limite:
Female
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Humans
/
Male
Idioma:
En
Revista:
Handb Clin Neurol
Ano de publicação:
2024
Tipo de documento:
Article