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Exploring the current landscape of single-cell RNA sequencing applications in gastric cancer research.
Awuah, Wireko Andrew; Roy, Sakshi; Tan, Joecelyn Kirani; Adebusoye, Favour Tope; Qiang, Zekai; Ferreira, Tomas; Ahluwalia, Arjun; Shet, Vallabh; Yee, Amanda Leong Weng; Abdul-Rahman, Toufik; Papadakis, Marios.
Afiliação
  • Awuah WA; Faculty of Medicine, Sumy State University, Sumy, Ukraine.
  • Roy S; School of Medicine, Queen's University Belfast, Belfast, UK.
  • Tan JK; Faculty of Medicine, University of St Andrews, St Andrews, UK.
  • Adebusoye FT; Faculty of Medicine, Sumy State University, Sumy, Ukraine.
  • Qiang Z; Department of Oncology & Metabolism, The University of Sheffield, Sheffield, UK.
  • Ferreira T; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Ahluwalia A; School of Medicine, Queen's University Belfast, Belfast, UK.
  • Shet V; Faculty of Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.
  • Yee ALW; Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Abdul-Rahman T; Faculty of Medicine, Sumy State University, Sumy, Ukraine.
  • Papadakis M; Department of Surgery II, University Hospital Witten-Herdecke, University of Witten-Herdecke, Wuppertal, Germany.
J Cell Mol Med ; 28(7): e18159, 2024 04.
Article em En | MEDLINE | ID: mdl-38494861
ABSTRACT
Gastric cancer (GC) represents a major global health burden and is responsible for a significant number of cancer-related fatalities. Its complex nature, characterized by heterogeneity and aggressive behaviour, poses considerable challenges for effective diagnosis and treatment. Single-cell RNA sequencing (scRNA-seq) has emerged as an important technique, offering unprecedented precision and depth in gene expression profiling at the cellular level. By facilitating the identification of distinct cell populations, rare cells and dynamic transcriptional changes within GC, scRNA-seq has yielded valuable insights into tumour progression and potential therapeutic targets. Moreover, this technology has significantly improved our comprehension of the tumour microenvironment (TME) and its intricate interplay with immune cells, thereby opening avenues for targeted therapeutic strategies. Nonetheless, certain obstacles, including tumour heterogeneity and technical limitations, persist in the field. Current endeavours are dedicated to refining protocols and computational tools to surmount these challenges. In this narrative review, we explore the significance of scRNA-seq in GC, emphasizing its advantages, challenges and potential applications in unravelling tumour heterogeneity and identifying promising therapeutic targets. Additionally, we discuss recent developments, ongoing efforts to overcome these challenges, and future prospects. Although further enhancements are required, scRNA-seq has already provided valuable insights into GC and holds promise for advancing biomedical research and clinical practice.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Pesquisa Biomédica Limite: Humans Idioma: En Revista: J Cell Mol Med Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Pesquisa Biomédica Limite: Humans Idioma: En Revista: J Cell Mol Med Ano de publicação: 2024 Tipo de documento: Article