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Bioinspired superhydrophobic surfaces with silver and nitric oxide-releasing capabilities to prevent device-associated infections and thrombosis.
Ozkan, Ekrem; Estes Bright, Lori M; Kumar, Anil; Pandey, Rashmi; Devine, Ryan; Francis, Divine; Ghalei, Sama; Ashcraft, Morgan; Maffe, Patrick; Brooks, Megan; Shome, Arpita; Garren, Mark; Handa, Hitesh.
Afiliação
  • Ozkan E; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Estes Bright LM; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Kumar A; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Pandey R; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Devine R; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Francis D; Department of Chemistry, University of Georgia, Athens, GA 30602, USA.
  • Ghalei S; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Ashcraft M; Pharmaceutical and Biomedical Sciences Department, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
  • Maffe P; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Brooks M; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Shome A; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Garren M; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
  • Handa H; School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA; Pharmaceutical and Biomedical Sciences Department, College of Pharmacy, University of Georgia, Athens, GA 30602, USA. Electronic address: hhanda@uga.edu.
J Colloid Interface Sci ; 664: 928-937, 2024 Jun 15.
Article em En | MEDLINE | ID: mdl-38503078
ABSTRACT
Bacteria-associated infections and thrombus formation are the two major complications plaguing the application of blood-contacting medical devices. Therefore, functionalized surfaces and drug delivery for passive and active antifouling strategies have been employed. Herein, we report the novel integration of bio-inspired superhydrophobicity with nitric oxide release to obtain a functional polymeric material with anti-thrombogenic and antimicrobial characteristics. The nitric oxide release acts as an antimicrobial agent and platelet inhibitor, while the superhydrophobic components prevent non-specific biofouling. Widely used medical-grade silicone rubber (SR) substrates that are known to be susceptible to biofilm and thrombus formation were dip-coated with fluorinated silicon dioxide (SiO2) and silver (Ag) nanoparticles (NPs) using an adhesive polymer as a binder. Thereafter, the resulting superhydrophobic (SH) SR substrates were impregnated with S-nitroso-N-acetylpenicillamine (SNAP, an NO donor) to obtain a superhydrophobic, Ag-bound, NO-releasing (SH-SiAgNO) surface. The SH-SiAgNO surfaces had the lowest amount of viable adhered E. coli (> 99.9 % reduction), S. aureus (> 99.8 % reduction), and platelets (> 96.1 % reduction) as compared to controls while demonstrating no cytotoxic effects on fibroblast cells. Thus, this innovative approach is the first to combine SNAP with an antifouling SH polymer surface that possesses the immense potential to minimize medical device-associated complications without using conventional systemic anticoagulation and antibiotic treatments.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Trombose / Anti-Infecciosos Limite: Humans Idioma: En Revista: J Colloid Interface Sci Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Trombose / Anti-Infecciosos Limite: Humans Idioma: En Revista: J Colloid Interface Sci Ano de publicação: 2024 Tipo de documento: Article