Investigating the role of salivary Interleukin-40 levels in diagnosing periodontal diseases.
Oral Dis
; 2024 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-38515006
ABSTRACT
BACKGROUND:
The present study aimed to analyze IL-40, IL-1ß, and MMP-8 levels in periodontitis as well as gingivitis and periodontal health, and to explore potential correlations between these biomarkers and standard clinical parameters. MATERIALS ANDMETHODS:
We collected saliva samples from 120 systemically healthy, non-smoking individuals aged between 18 and 63 years. These individuals were divided into three groups healthy controls [S], gingivitis [G], and stage III grade B periodontitis [P]. IL-40, IL-1ß, and MMP-8 levels in saliva samples were analyzed by ELISA.RESULTS:
We observed significantly elevated salivary IL-40 levels in the G group compared to the S group (p = 0.003). We found significantly higher salivary IL-1ß levels in the P group compared to both the S and G groups (p = 0.000). Salivary MMP-8 levels were significantly higher in the P group than in the S group (p = 0.016).CONCLUSION:
Our study suggests that IL-40 and IL-1ß may serve as effective salivary biomarkers for diagnosing gingivitis, while MMP-8 and IL-1ß may be effective for distinguishing periodontitis. Based on our study's findings, it can be stated that IL-40 may serve as a new and effective biomarker for distinguishing individuals with gingivitis from healthy ones.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Oral Dis
Ano de publicação:
2024
Tipo de documento:
Article