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Associations Between Dietary Patterns and Kidney Health Assessed in the Population-Based CHRIS Study Using Reduced Rank Regression.
Barbieri, Giulia; Garcia-Larsen, Vanessa; Lundin, Rebecca; Fujii, Ryosuke; Melotti, Roberto; Gögele, Martin; Christopher, Kenneth B; Cazzoletti, Lucia; Pramstaller, Peter P; Zanolin, Maria Elisabetta; Pattaro, Cristian; Hantikainen, Essi.
Afiliação
  • Barbieri G; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy. Electronic address: giulia.barbieri@eurac.edu.
  • Garcia-Larsen V; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  • Lundin R; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy.
  • Fujii R; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy; Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan.
  • Melotti R; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy.
  • Gögele M; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy.
  • Christopher KB; Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Cazzoletti L; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy.
  • Zanolin ME; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Pattaro C; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy.
  • Hantikainen E; Institute for Biomedicine, Eurac Research, Bolzano, Bozen, Italy. Electronic address: essimarjatta.hantikainen@eurac.edu.
J Ren Nutr ; 34(5): 427-437, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38521380
ABSTRACT

OBJECTIVE:

While diet plays a key role in chronic kidney disease (CKD) management, the potential for diet to impact CKD prevention in the general population is less clear. Using a priori knowledge, we derived disease-related dietary patterns (DPs) through reduced rank regression (RRR) and investigated associations with kidney function, separately focusing on generally healthy individuals and those with self-reported kidney diseases, hypertension, or diabetes mellitus.

METHODS:

Eight thousand six hundred eighty-six participants from the population-based Cooperative Health Research in South Tyrol study were split into a group free of kidney disease, hypertension and diabetes (n = 6,133) and a group with any of the 3 conditions (n = 2,553). Diet was assessed through the self-administered Global Allergy and Asthma Network of Excellence food frequency questionnaire and DPs were derived through RRR selecting food frequency questionnaire-derived sodium, potassium, phosphorus, and protein intake as mediators. Outcomes were creatinine-based estimated glomerular filtration rate, urinary albumin-to-creatinine ratio, CKD and microalbuminuria. Multiple linear and logistic models were used to assess associations between RRR-based DPs and kidney outcomes separately in the 2 analytic groups.

RESULTS:

We identified 3 DPs, where high adherence reflected high levels of all nutrients (DP1), high potassium-phosphorus and low protein-sodium levels (DP2), and low potassium-sodium and high protein-phosphorus levels (DP3), respectively. We observed heterogeneous associations with kidney outcomes, varying by analytic group and sex. Kidney outcomes were much more strongly associated with DPs than with single nutrients.

CONCLUSION:

RRR is a feasible approach to estimate disease-related DPs and explore the combined effects of nutrients on kidney health. Heterogeneous associations across kidney outcomes suggest possible specificity to kidney function or damage. In individuals reporting kidney disease, hypertension or diabetes, specific dietary habits were associated with better kidney health, indicating that disease-specific dietary interventions can be effective for disease control.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta / Insuficiência Renal Crônica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Ren Nutr Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta / Insuficiência Renal Crônica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Ren Nutr Ano de publicação: 2024 Tipo de documento: Article