Heart rate variability analysis in obstructive sleep apnea patients with daytime sleepiness.
Sleep
; 47(6)2024 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-38531670
ABSTRACT
STUDY OBJECTIVES:
Recent studies suggest that sleepy patients with obstructive sleep apnea (OSA) are at higher risk for incident cardiovascular disease. This study assessed cardiac autonomic function in sleepy versus non-sleepy patients with OSA using heart rate variability (HRV) analysis. We hypothesized that HRV profiles of sleepy patients would indicate higher cardiovascular risk.METHODS:
Electrocardiograms (ECG) derived from polysomnograms (PSG) collected by the Sydney Sleep Biobank were used to study HRV in groups of sleepy (ESSâ ≥â 10) and non-sleepy OSA patients (ESSâ <â 10). HRV parameters were averaged across available ECG signals during N2 sleep.RESULTS:
A total of 421 patients were evaluated, with a mean age of 54 (14) years, body mass index of 33 (9) kg/m2, apnea-hypopnea index of 21 (28) events/h, and 66% male. The sleepy group consisted of 119 patients and the non-sleepy group 302 patients. Sleepy patients exhibited lower HRV values for root mean square successive difference (RMSSD, pâ =â 0.028), total power (TP, pâ =â 0.031), absolute low frequency (LF, pâ =â 0.045), and high-frequency (HF, pâ =â 0.010) power compared to non-sleepy patients. Sleepy patients with moderate-to-severe OSA exhibited lower HRV values for (RMSSD, pâ =â 0.045; TP, pâ =â 0.052), absolute LF (pâ =â 0.051), and HF power (pâ =â 0.025). There were no differences in other time and frequency domain HRV markers.CONCLUSIONS:
This study shows a trend toward parasympathetic withdrawal in sleepy OSA patients, particularly in moderate-to-severe cases, lending mechanistic support to the link between the sleepy phenotype and CVD risk in OSA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissonografia
/
Apneia Obstrutiva do Sono
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Eletrocardiografia
/
Frequência Cardíaca
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Sleep
/
Sleep (New York, N.Y. Online)
Ano de publicação:
2024
Tipo de documento:
Article