Transmembrane protein 25 abrogates monomeric EGFR-driven STAT3 activation in triple-negative breast cancer.
MedComm (2020)
; 5(4): e492, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38532948
ABSTRACT
In wild-type cells, TMEM25 physically associates with EGFR monomer and suppresses the EGFR-mediated STAT3 phosphorylation, which results in the sequestration of unphosphorylated STAT3 in the cytoplasm. In TMEM-/- cells, EGFR monomer phosphorylates STAT3 at the basal level.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
MedComm (2020)
Ano de publicação:
2024
Tipo de documento:
Article