Research progress of the netrins and their receptors in cancer.
J Cell Mol Med
; 28(8): e18241, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38546656
ABSTRACT
Netrins, a family of secreted and membrane-associated proteins, can regulate axonal guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis. Four secreted netrins (netrin 1, 3, 4 and 5) and two glycosylphosphatidylinositols-anchored membrane proteins, netrin-G1 and G2, have been identified in mammals. Netrins and their receptors can serve as a biomarker and molecular therapeutic target for pathological differentiation, diagnosis and prognosis of malignant cancers. We review here the potential roles of the netrins family and their receptors in cancer.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias
Limite:
Animals
Idioma:
En
Revista:
J Cell Mol Med
Ano de publicação:
2024
Tipo de documento:
Article