Your browser doesn't support javascript.
loading
Diving into the proteomic atlas of SARS-CoV-2 infected cells.
Carregari, Victor C; Reis-de-Oliveira, Guilherme; Crunfli, Fernanda; Smith, Bradley J; de Souza, Gabriela Fabiano; Muraro, Stéfanie Primon; Saia-Cereda, Veronica M; Vendramini, Pedro H; Baldasso, Paulo A; Silva-Costa, Lícia C; Zuccoli, Giuliana S; Brandão-Teles, Caroline; Antunes, André; Valença, Aline F; Davanzo, Gustavo G; Virgillio-da-Silva, João Victor; Dos Reis Araújo, Thiago; Guimarães, Raphael Campos; Chaim, Felipe David Mendonça; Chaim, Elinton Adami; Kawagosi Onodera, Carolina Mie; Ludwig, Raissa Guimarães; Saccon, Tatiana Dandolini; Damásio, André R L; Leiria, Luiz Osório S; Vinolo, Marco Aurélio R; Farias, Alessandro S; Moraes-Vieira, Pedro M; Mori, Marcelo A; Módena, José Luiz P; Martins-de-Souza, Daniel.
Afiliação
  • Carregari VC; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. corasolla@gmail.com.
  • Reis-de-Oliveira G; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Crunfli F; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Smith BJ; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • de Souza GF; Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
  • Muraro SP; Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
  • Saia-Cereda VM; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Vendramini PH; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Baldasso PA; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Silva-Costa LC; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Zuccoli GS; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Brandão-Teles C; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Antunes A; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Valença AF; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Davanzo GG; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Virgillio-da-Silva JV; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
  • Dos Reis Araújo T; Department of Pharmacology, Ribeirão Preto Medical School (FMRP), University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
  • Guimarães RC; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil.
  • Chaim FDM; Obesity and Comorbidities Research Center (OCRC), Campinas, São Paulo, Brazil.
  • Chaim EA; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil.
  • Kawagosi Onodera CM; Obesity and Comorbidities Research Center (OCRC), Campinas, São Paulo, Brazil.
  • Ludwig RG; Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
  • Saccon TD; Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
  • Damásio ARL; Hematology-Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
  • Leiria LOS; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Vinolo MAR; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Farias AS; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Moraes-Vieira PM; Department of Pharmacology, Ribeirão Preto Medical School (FMRP), University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
  • Mori MA; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil.
  • Módena JLP; Obesity and Comorbidities Research Center (OCRC), Campinas, São Paulo, Brazil.
  • Martins-de-Souza D; Hematology-Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
Sci Rep ; 14(1): 7375, 2024 03 28.
Article em En | MEDLINE | ID: mdl-38548777
ABSTRACT
The COVID-19 pandemic was initiated by the rapid spread of a SARS-CoV-2 strain. Though mainly classified as a respiratory disease, SARS-CoV-2 infects multiple tissues throughout the human body, leading to a wide range of symptoms in patients. To better understand how SARS-CoV-2 affects the proteome from cells with different ontologies, this work generated an infectome atlas of 9 cell models, including cells from brain, blood, digestive system, and adipocyte tissue. Our data shows that SARS-CoV-2 infection mainly trigger dysregulations on proteins related to cellular structure and energy metabolism. Despite these pivotal processes, heterogeneity of infection was also observed, highlighting many proteins and pathways uniquely dysregulated in one cell type or ontological group. These data have been made searchable online via a tool that will permit future submissions of proteomic data ( https//reisdeoliveira.shinyapps.io/Infectome_App/ ) to enrich and expand this knowledgebase.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article