How can we establish animal models of HIV-associated lymphoma?
Animal Model Exp Med
; 7(4): 484-496, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38567763
ABSTRACT
Human immunodeficiency virus (HIV) infection is strongly associated with a heightened incidence of lymphomas. To mirror the natural course of human HIV infection, animal models have been developed. These models serve as valuable tools to investigate disease pathobiology, assess antiretroviral and immunomodulatory drugs, explore viral reservoirs, and develop eradication strategies. However, there are currently no validated in vivo models of HIV-associated lymphoma (HAL), hampering progress in this crucial domain, and scant attention has been given to developing animal models dedicated to studying HAL, despite their pivotal role in advancing knowledge. This review provides a comprehensive overview of the existing animal models of HAL, which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Modelos Animais de Doenças
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Animal Model Exp Med
Ano de publicação:
2024
Tipo de documento:
Article