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Association of Coronary Wall Thickening and Diminished Diastolic Function in Asymptomatic, Low Cardiovascular Disease-Risk Persons Living with HIV.
Abd-Elmoniem, Khaled Z; Ishaq, Hadjira; Purdy, Julia; Matta, Jatin; Hamimi, Ahmed; Hannoush, Hwaida; Hadigan, Colleen; Gharib, Ahmed M.
Afiliação
  • Abd-Elmoniem KZ; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
  • Ishaq H; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
  • Purdy J; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
  • Matta J; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
  • Hamimi A; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
  • Hannoush H; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
  • Hadigan C; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
  • Gharib AM; From the Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases (K.Z.A.E., H.I., J.M., A.H., A.M.G.), Critical Care Medicine Department, National Institutes of Health Clinical Center (J.P.), National Human Genome Research Institute (H.H.), and Natio
Radiol Cardiothorac Imaging ; 6(2): e230102, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38573125
ABSTRACT
Purpose To assess early subclinical coronary artery disease (CAD) burden and its relation to myocardial function in asymptomatic persons living with HIV (PLWH) who are at low risk for cardiovascular disease (CVD). Materials and Methods In this prospective, HIPAA-compliant study (ClinicalTrials.gov NCT01656564 and NCT01399385) conducted from April 2010 to May 2013, 74 adult PLWH without known CVD and 25 matched healthy controls underwent coronary MRI to measure coronary vessel wall thickness (VWT) and echocardiography to assess left ventricular function. Univariable and multivariable linear regression analyses were used to evaluate statistical associations. Results For PLWH, the mean age was 49 years ± 11 (SD), and the median Framingham risk score was 3.2 (IQR, 0.5-6.6); for matched healthy controls, the mean age was 46 years ± 8 and Framingham risk score was 2.3 (IQR, 0.6-6.1). PLWH demonstrated significantly greater coronary artery VWT than did controls (1.47 mm ± 0.22 vs 1.34 mm ± 0.18; P = .006) and a higher left ventricular mass index (LVMI) (77 ± 16 vs 70 ± 13; P = .04). Compared with controls, PLWH showed altered association between coronary artery VWT and both E/A (ratio of left ventricular-filling peak blood flow velocity in early diastole [E wave] to that in late diastole [A wave]) (P = .03) and LVMI (P = .04). In the PLWH subgroup analysis, coronary artery VWT increase was associated with lower E/A (P < .001) and higher LVMI (P = .03), indicating restricted diastolic function. In addition, didanosine exposure was associated with increased coronary artery VWT and decreased E/A ratio. Conclusion Asymptomatic low-CVD-risk PLWH demonstrated increased coronary artery VWT in association with impaired diastolic function, which may be amenable to follow-up studies of coronary pathogenesis to identify potential effects on the myocardium and risk modification strategies. Keywords Coronary Vessel Wall Thickness, Diastolic Function, HIV, MRI, Echocardiography, Atherosclerosis Clinical trial registration nos. NCT01656564 and NCT01399385 Supplemental material is available for this article. © RSNA, 2024.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Infecções por HIV Limite: Adult / Humans / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Infecções por HIV Limite: Adult / Humans / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Ano de publicação: 2024 Tipo de documento: Article