The CXCR4 might be a potential biomarker for esophageal squamous cell carcinoma: A meta-analysis.
Medicine (Baltimore)
; 103(14): e37681, 2024 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-38579048
ABSTRACT
OBJECTIVE:
To evaluate the relationship between CXCL12/CXCR4 and the progress, prognosis of esophageal squamous cell carcinoma (ESCC), providing evidence for potential early diagnosis, clinical treatment, prognosis evaluation, and therapeutic target of ESCC.METHODS:
Databases of PubMed, the Cochrane Library, Embase, and Web of Science were searched for the relationship between CXCL12/CXCR4 and clinicopathological characteristics and survival time of ESCC. Stata16.0 software was used to conduct meta-analysis.RESULTS:
A total of 10 studies involving 1216 cases of patients with ESCC were included in our study. The results indicated that high-level expression of CXCR4 was significantly correlated with tumor differentiation [ORâ =â 0.69, 95% confidence interval (CI) (0.50, 0.97)], tumor infiltration [ORâ =â 0.39, 95% CI (0.25, 0.61)], lymph node metastasis [ORâ =â 0.36, 95% CI (0.21, 0.61)], clinical stage [ORâ =â 0.33, 95% CI (0.24, 0.45)] of ESCC. The expression of CXCR4 was also significantly correlated with OS [HRâ =â 2.00, 95% CI (1.63, 2.45)] and disease-free survival [HRâ =â 1.76, 95% CI (1.44, 2.15)] in patients of ESCC after surgical resection. No significant relationship was observed between the expression of CXCL12 and the clinicopathological characteristics of ESCC.CONCLUSION:
CXCR4 might be a potential biomarker for the progress and prognosis evaluation, and therapeutic target for ESCC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Carcinoma de Células Escamosas do Esôfago
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2024
Tipo de documento:
Article