Evolution and the critical role of the microbiota in the reduced mental and physical health associated with low socioeconomic status (SES).
Neurosci Biobehav Rev
; 161: 105653, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38582194
ABSTRACT
The evolution of the gut-microbiota-brain axis in animals reveals that microbial inputs influence metabolism, the regulation of inflammation and the development of organs, including the brain. Inflammatory, neurodegenerative and psychiatric disorders are more prevalent in people of low socioeconomic status (SES). Many aspects of low SES reduce exposure to the microbial inputs on which we are in a state of evolved dependence, whereas the lifestyle of wealthy citizens maintains these exposures. This partially explains the health deficit of low SES, so focussing on our evolutionary history and on environmental and lifestyle factors that distort microbial exposures might help to mitigate that deficit. But the human microbiota is complex and we have poor understanding of its functions at the microbial and mechanistic levels, and in the brain. Perhaps its composition is more flexible than the microbiota of animals that have restricted habitats and less diverse diets? These uncertainties are discussed in relation to the encouraging but frustrating results of attempts to treat psychiatric disorders by modulating the microbiota.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Classe Social
/
Evolução Biológica
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Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Revista:
Neurosci Biobehav Rev
/
Neurosci. biobehav. rev
/
Neuroscience and biobehavioral reviews
Ano de publicação:
2024
Tipo de documento:
Article