Robust dual-angle T 1 measurement in magnetization transfer spectroscopy by time-optimal control.
NMR Biomed
; 37(9): e5151, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38583871
ABSTRACT
Magnetization transfer spectroscopy relies heavily on the robust determination of T 1 relaxation times of nuclei participating in metabolic exchange. Challenges arise due to the use of surface RF coils for transmission (high B 1 + variation) and the broad resonance band of most X nuclei. These challenges are particularly pronounced when fast T 1 mapping methods, such as the dual-angle method, are employed. Consequently, in this work, we develop resonance offset and B 1 + robust excitation RF pulses for 31P magnetization transfer spectroscopy at 7T through ensemble-based time-optimal control. In our approach, we introduce a cost functional for designing robust pulses, incorporating the full Bloch equations as constraints, which are solved using symmetric operator splitting techniques. The optimal control design of the RF pulses developed demonstrates improved accuracy, desired phase properties, and reduced RF power when applied to dual-angle T 1 mapping, thereby improving the precision of exchange-rate measurements, as demonstrated in a preclinical in vivo study quantifying brain creatine kinase activity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectroscopia de Ressonância Magnética
Limite:
Animals
Idioma:
En
Revista:
NMR Biomed
Ano de publicação:
2024
Tipo de documento:
Article