Neuroimmunomodulatory effect of Nitric Oxide on chronic wound healing after photodynamic therapy.
Photodiagnosis Photodyn Ther
; 47: 104078, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38588874
ABSTRACT
Neuroimmunomodulation is the capacity of the nervous system to regulate immune processes. The existence of neurotransmitter receptors in immune cells enables this phenomenon to take place. Neuronal mediators possess the capacity to direct and control several occurrences during the wound healing process. Nitric oxide (NO) functions as a neuromodulator, playing a crucial role in the regulation of vascular tone and blood pressure with antimicrobial properties. Photodynamic therapy has been shown to augment the function of immune cells involved in the healing process of venous leg ulcers. Nitric oxide can be secreted into the extracellular environment by these cells. In lesions treated with PDT, the synthesis of iNOs (the enzyme that releases NO) increased, as demonstrated by the experimental results. Therefore the significance of PDT in enhancing the clinical condition of the lesion is thus highlighted.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Cicatrização
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Fármacos Fotossensibilizantes
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Óxido Nítrico
Limite:
Animals
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Humans
Idioma:
En
Revista:
Photodiagnosis Photodyn Ther
Ano de publicação:
2024
Tipo de documento:
Article