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Sex differences orchestrated by androgens at single-cell resolution.
Li, Fei; Xing, Xudong; Jin, Qiqi; Wang, Xiang-Ming; Dai, Pengfei; Han, Ming; Shi, Huili; Zhang, Ze; Shao, Xianlong; Peng, Yunyi; Zhu, Yiqin; Xu, Jiayi; Li, Dan; Chen, Yu; Wu, Wei; Wang, Qiao; Yu, Chen; Chen, Luonan; Bai, Fan; Gao, Dong.
Afiliação
  • Li F; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Xing X; Biomedical Pioneering Innovation Center (BIOPIC), Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University, Beijing, China.
  • Jin Q; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Wang XM; University of Chinese Academy of Sciences, Beijing, China.
  • Dai P; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Han M; Biomedical Pioneering Innovation Center (BIOPIC), Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University, Beijing, China.
  • Shi H; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Zhang Z; University of Chinese Academy of Sciences, Beijing, China.
  • Shao X; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Peng Y; University of Chinese Academy of Sciences, Beijing, China.
  • Zhu Y; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Xu J; University of Chinese Academy of Sciences, Beijing, China.
  • Li D; Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
  • Chen Y; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Wu W; University of Chinese Academy of Sciences, Beijing, China.
  • Wang Q; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Yu C; University of Chinese Academy of Sciences, Beijing, China.
  • Chen L; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
  • Bai F; Shanghai Normal University, Shanghai, China.
  • Gao D; Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nature ; 629(8010): 193-200, 2024 May.
Article em En | MEDLINE | ID: mdl-38600383
ABSTRACT
Sex differences in mammalian complex traits are prevalent and are intimately associated with androgens1-7. However, a molecular and cellular profile of sex differences and their modulation by androgens is still lacking. Here we constructed a high-dimensional single-cell transcriptomic atlas comprising over 2.3 million cells from 17 tissues in Mus musculus and explored the effects of sex and androgens on the molecular programs and cellular populations. In particular, we found that sex-biased immune gene expression and immune cell populations, such as group 2 innate lymphoid cells, were modulated by androgens. Integration with the UK Biobank dataset revealed potential cellular targets and risk gene enrichment in antigen presentation for sex-biased diseases. This study lays the groundwork for understanding the sex differences orchestrated by androgens and provides important evidence for targeting the androgen pathway as a broad therapeutic strategy for sex-biased diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células / Caracteres Sexuais / Análise de Célula Única / Transcriptoma / Androgênios Limite: Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células / Caracteres Sexuais / Análise de Célula Única / Transcriptoma / Androgênios Limite: Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2024 Tipo de documento: Article