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Prevalence of meropenem-resistant Pseudomonas Aeruginosa in Ethiopia: a systematic review and meta­analysis.
Gobezie, Mengistie Yirsaw; Hassen, Minimize; Tesfaye, Nuhamin Alemayehu; Solomon, Tewodros; Demessie, Mulat Belete; Kassa, Tesfaye Dessale; Wendie, Teklehaimanot Fentie; Andualem, Abel; Alemayehu, Ermiyas; Belayneh, Yaschilal Muche.
Afiliação
  • Gobezie MY; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia. zemen.girum@gmail.com.
  • Hassen M; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  • Tesfaye NA; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  • Solomon T; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  • Demessie MB; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  • Kassa TD; Department of Clinical Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
  • Wendie TF; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  • Andualem A; Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  • Alemayehu E; Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  • Belayneh YM; Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Antimicrob Resist Infect Control ; 13(1): 37, 2024 Apr 10.
Article em En | MEDLINE | ID: mdl-38600535
ABSTRACT

INTRODUCTION:

Antimicrobial resistance (AMR) is a pressing global health concern, particularly pronounced in low-resource settings. In Ethiopia, the escalating prevalence of carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa) poses a substantial threat to public health.

METHODS:

A comprehensive search of databases, including PubMed, Scopus, Embase, Hinari, and Google Scholar, identified relevant studies. Inclusion criteria encompassed observational studies reporting the prevalence of meropenem-resistant P. aeruginosa in Ethiopia. Quality assessment utilized JBI checklists. A random-effects meta-analysis pooled data on study characteristics and prevalence estimates, with subsequent subgroup and sensitivity analyses. Publication bias was assessed graphically and statistically.

RESULTS:

Out of 433 studies, nineteen, comprising a total sample of 11,131, met inclusion criteria. The pooled prevalence of meropenem-resistant P. aeruginosa was 15% (95% CI 10-21%). Significant heterogeneity (I2 = 83.6%) was observed, with the number of P. aeruginosa isolates identified as the primary source of heterogeneity (p = 0.127). Subgroup analysis by infection source revealed a higher prevalence in hospital-acquired infections (28%, 95% CI 10, 46) compared to community settings (6%, 95% CI 2, 11). Geographic based subgroup analysis indicated the highest prevalence in the Amhara region (23%, 95% CI 8, 38), followed by Addis Ababa (21%, 95% CI 11, 32), and lower prevalence in the Oromia region (7%, 95% CI 4, 19). Wound samples exhibited the highest resistance (25%, 95% CI 25, 78), while sputum samples showed the lowest prevalence. Publication bias, identified through funnel plot examination and Egger's regression test (p < 0.001), execution of trim and fill analysis resulted in an adjusted pooled prevalence of (3.7%, 95% CI 2.3, 9.6).

CONCLUSION:

The noteworthy prevalence of meropenem resistance among P. aeruginosa isolates in Ethiopia, particularly in healthcare settings, underscores the urgency of implementing strict infection control practices and antibiotic stewardship. Further research is imperative to address and mitigate the challenges posed by antimicrobial resistance in the country.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Infecções por Pseudomonas / Anti-Infecciosos Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Antimicrob Resist Infect Control / Antimicrob. resist. infect. control / Antimicrobial resistance and infection control Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Infecções por Pseudomonas / Anti-Infecciosos Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Antimicrob Resist Infect Control / Antimicrob. resist. infect. control / Antimicrobial resistance and infection control Ano de publicação: 2024 Tipo de documento: Article