Transplacental transfer of maternal antibodies following immunization with recombinant pertussis vaccines during pregnancy: Real-world evidence.
Int J Infect Dis
; 144: 107047, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38609035
ABSTRACT
AIM/OBJECTIVE:
This study investigates placental antibody transfer following recombinant pertussis vaccination in pregnancy in a real-world setting.METHODS:
This postmarketing observational study recruited pregnant women vaccinated with monovalent recombinant acellular pertussis (aP) vaccine (aPgen; n = 199) or combined to tetanus-diphtheria (TdaPgen; n = 200), or Td-vaccine only (n = 54). Pregnancy, delivery, and neonatal outcomes were assessed. Cord blood was collected postdelivery and pertussis toxin (PT)-IgG, filamentous hemagglutinin (FHA)-IgG, and PT-neutralizing antibodies (PT-Nab) were assessed.RESULTS:
No adverse pregnancy, delivery, or neonatal outcomes attributed to aPgen, TdaPgen, or Td vaccination were reported. High anti-PT antibody levels were detected in cord samples from women vaccinated with aPgen (geometric mean concentration [GMC] PT-IgG 206.1 IU/ml, 95% confidence intervals [CI] 164.3-258.6; geometric mean titer [GMT] PT-Nab 105.3 IU/ml, 95% CI 81.7-135.8) or TdaPgen (GMC PT-IgG 153.1 IU/ml, 95% CI 129.1-181.5; GMT PT-Nab 81.5 IU/ml, 95% CI 66.4-100.0). In the Td-only group, anti-PT antibodies were low (GMC PT-IgG 6.5 IU/ml, 95% CI 4.9-8.8; GMT PT-Nab 3.8 IU/ml, 95% CI 2.8-5.1). The same was found for FHA-IgG. Recombinant pertussis vaccination at <27 or 27-36 weeks gestation induced similar cord pertussis antibody levels.CONCLUSION:
This first real-world study confirms that recombinant pertussis vaccination in the second or third trimester of pregnancy results in high levels of passive immunity in infants. Thai Clinical Trial Registry TCTR20200528006.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coqueluche
/
Imunidade Materno-Adquirida
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Anticorpos Antibacterianos
Limite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Int J Infect Dis
Ano de publicação:
2024
Tipo de documento:
Article