Your browser doesn't support javascript.
loading
Divergent Associations of Slow-Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid-Beta.
Rosenblum, Yevgenia; Pereira, Mariana; Stange, Oliver; Weber, Frederik D; Bovy, Leonore; Tzioridou, Sofia; Lancini, Elisa; Neville, David A; Klein, Nadja; de Wolff, Timo; Stritzke, Mandy; Kersten, Iris; Uhr, Manfred; Claassen, Jurgen A H R; Steiger, Axel; Verbeek, Marcel M; Dresler, Martin.
Afiliação
  • Rosenblum Y; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Pereira M; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Stange O; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Weber FD; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Bovy L; Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
  • Tzioridou S; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Lancini E; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Neville DA; Otto von Guericke University Magdeburg, German Center for Neurodegenerative Diseases, Magdeburg, Germany.
  • Klein N; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany.
  • de Wolff T; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Stritzke M; Chair of Uncertainty Quantification and Statistical Learning, Department of Statistics, Technische Universität Dortmund, Dortmund, Germany.
  • Kersten I; Technische Universität Braunschweig, Institut für Analysis und Algebra, Braunschweig, Germany.
  • Uhr M; Technische Universität Braunschweig, Institut für Analysis und Algebra, Braunschweig, Germany.
  • Claassen JAHR; Departments of Neurology and Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Steiger A; Max Planck Institute of Psychiatry, Munich, Germany.
  • Verbeek MM; Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands.
  • Dresler M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Ann Neurol ; 96(1): 46-60, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38624158
ABSTRACT

OBJECTIVE:

Recent evidence shows that during slow-wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid-beta protein. Poor sleep or elevated cortisol levels can worsen amyloid-beta clearance, potentially leading to the formation of amyloid plaques, a neuropathological hallmark of Alzheimer disease. Here, we explored how nocturnal neural and endocrine activity affects amyloid-beta fluctuations in the peripheral blood.

METHODS:

We acquired simultaneous polysomnography and all-night blood sampling in 60 healthy volunteers aged 20-68 years. Nocturnal plasma concentrations of amyloid-beta-40, amyloid-beta-42, cortisol, and growth hormone were assessed every 20 minutes. Amyloid-beta fluctuations were modeled with sleep stages, (non)oscillatory power, and hormones as predictors while controlling for age and participant-specific random effects.

RESULTS:

Amyloid-beta-40 and amyloid-beta-42 levels correlated positively with growth hormone concentrations, SWS proportion, and slow-wave (0.3-4Hz) oscillatory and high-band (30-48Hz) nonoscillatory power, but negatively with cortisol concentrations and rapid eye movement sleep (REM) proportion measured 40-100 minutes previously (all t values > |3|, p values < 0.003). Older participants showed higher amyloid-beta-40 levels.

INTERPRETATION:

Slow-wave oscillations are associated with higher plasma amyloid-beta levels, whereas REM sleep is related to decreased amyloid-beta plasma levels, possibly representing changes in central amyloid-beta production or clearance. Strong associations between cortisol, growth hormone, and amyloid-beta presumably reflect the sleep-regulating role of the corresponding releasing hormones. A positive association between age and amyloid-beta-40 may indicate that peripheral clearance becomes less efficient with age. ANN NEUROL 2024;9646-60.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono REM / Peptídeos beta-Amiloides / Polissonografia / Sono de Ondas Lentas Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono REM / Peptídeos beta-Amiloides / Polissonografia / Sono de Ondas Lentas Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article