Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats.
Open Vet J
; 14(1): 292-303, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38633147
ABSTRACT
Background:
Paracetamol (PCM) overdosing induces hepatotoxicity, which can result in death if the dose is high enough and the patients are not given N-acetyl cysteine. Berberine (BBR) has a variety of biological proprieties including anti-inflammatory and antioxidant activities.Aim:
Assessment of the potential effect of BBR and selenium when used alone or together on the PCM-induced acute hepatic toxicity in rats.Methods:
This research involved 40 clinically healthy mature adult male albino rats, their weights ranged from 150 to 200 g and housed in standard conditions. Our study involved evaluating the potential effect of BBR and selenium when used alone or together on the PCM-induced acute hepatic toxicity via estimation of the liver function tests, determination of the antioxidant enzyme activities, lipid peroxidation markers, immune-modulatory effects, liver histopathological, and immunohistochemical studies.Results:
Co-treatment of BBR (150 mg/kg BW) with selenium (5 mg/kg BW) showed significant improvement in the liver function parameters, the antioxidant enzyme activities, reduction in the nitric oxide (NO), lysozyme, malondialdehyde (MDA), TNF-α, and TGF-ß1 levels, and marked elevation in the IgM levels.Conclusion:
Altogether, BBR, selenium, or both augment antioxidant activity and alleviate PCM-induced hepatic toxicity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Berberina
Limite:
Animals
/
Humans
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Male
Idioma:
En
Revista:
Open Vet J
/
Open vet. j
/
Open veterinary journal
Ano de publicação:
2024
Tipo de documento:
Article