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Automatic grading of intervertebral disc degeneration in lumbar dog spines.
Niemeyer, Frank; Galbusera, Fabio; Beukers, Martijn; Jonas, René; Tao, Youping; Fusellier, Marion; Tryfonidou, Marianna A; Neidlinger-Wilke, Cornelia; Kienle, Annette; Wilke, Hans-Joachim.
Afiliação
  • Niemeyer F; Institute for Orthopaedic Research and Biomechanics, Centre for Trauma Research University Hospital Ulm Ulm Germany.
  • Galbusera F; SpineServ GmbH & Co. KG Ulm Germany.
  • Beukers M; Institute for Orthopaedic Research and Biomechanics, Centre for Trauma Research University Hospital Ulm Ulm Germany.
  • Jonas R; SpineServ GmbH & Co. KG Ulm Germany.
  • Tao Y; Head Research Group Spine, Spine Center Schulthess Clinic Zürich Switzerland.
  • Fusellier M; Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands.
  • Tryfonidou MA; Institute for Orthopaedic Research and Biomechanics, Centre for Trauma Research University Hospital Ulm Ulm Germany.
  • Neidlinger-Wilke C; SpineServ GmbH & Co. KG Ulm Germany.
  • Kienle A; Maitre de Conférences Imagerie Médicale, INSERM UMRS1229, Regenerative Medicine and Skeleton RMeS Team STEP School of Dental Surgery Nantes France.
  • Wilke HJ; Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands.
JOR Spine ; 7(2): e1326, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38633660
ABSTRACT

Background:

Intervertebral disc degeneration is frequent in dogs and can be associated with symptoms and functional impairments. The degree of disc degeneration can be assessed on T2-weighted MRI scans using the Pfirrmann classification scheme, which was developed for the human spine. However, it could also be used to quantify the effectiveness of disc regeneration therapies. We developed and tested a deep learning tool able to automatically score the degree of disc degeneration in dog spines, starting from an existing model designed to process images of human patients.

Methods:

MRI midsagittal scans of 5991 lumbar discs of dog patients were collected and manually evaluated with the Pfirrmann scheme and a modified scheme with transitional grades. A deep learning model was trained to classify the disc images based on the two schemes and tested by comparing its performance with the model processing human images.

Results:

The determination of the Pfirrmann grade showed sensitivities higher than 83% for all degeneration grades, except for grade 5, which is rare in dog spines, and high specificities. In comparison, the correspondent human model had slightly higher sensitivities, on average 90% versus 85% for the canine model. The modified scheme with the fractional grades did not show significant advantages with respect to the original Pfirrmann grades.

Conclusions:

The novel tool was able to accurately and reliably score the severity of disc degeneration in dogs, although with a performance inferior than that of the human model. The tool has potential in the clinical management of disc degeneration in canine patients as well as in longitudinal studies evaluating regenerative therapies in dogs used as animal models of human disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JOR Spine Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JOR Spine Ano de publicação: 2024 Tipo de documento: Article