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Nematode Uptake Preference toward Different Nanoplastics through Avoidance Behavior Regulation.
He, Caijiao; Lin, Xintong; Li, Pei; Hou, Jie; Yang, Meirui; Sun, Ziyi; Zhang, Shuang; Yang, Kun; Lin, Daohui.
Afiliação
  • He C; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
  • Lin X; School of Energy and Environment, City University of Hong Kong, Kowloon, Hong Kong China.
  • Li P; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
  • Hou J; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
  • Yang M; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
  • Sun Z; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
  • Zhang S; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
  • Yang K; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
  • Lin D; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
ACS Nano ; 18(17): 11323-11334, 2024 Apr 30.
Article em En | MEDLINE | ID: mdl-38635335
ABSTRACT
Expounding bioaccumulation pathways of nanoplastics in organisms is a prerequisite for assessing their ecological risks in the context of global plastic pollution. Invertebrate uptake preference toward nanoplastics is a key initial step of nanoplastic food chain transport that controls their global biosafety, while the biological regulatory mechanism remains unclear. Here, we reveal a preferential uptake mechanism involving active avoidance of nanoplastics by Caenorhabditis elegans and demonstrate the relationship between the uptake preference and nanoplastic characteristics. Nanoplastics with 100 nm in size or positive surface charges induce stronger avoidance due to higher toxicity, causing lower accumulation in nematodes, compared to the 500 nm-sized or negatively charged nanoplastics, respectively. Further evidence showed that nematodes did not actively ingest any types of nanoplastics, while different nanoplastics induced defense responses in a toxicity-dependent manner and distinctly stimulated the avoidance behavior of nematodes (ranged from 15.8 to 68.7%). Transcriptomics and validations using mutants confirmed that the insulin/IGF signaling (IIS) pathway is essential for the selective avoidance of nanoplastics. Specifically, the activation of DAF-16 promoted the IIS pathway-mediated defense against nanoplastics and stimulated the avoidance behavior, increasing the survival chances of nematodes. Considering the genetical universality of this defense response among invertebrates, such an uptake preference toward certain nanoplastics could lead to cascaded risks in the ecosystem.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 15_ODS3_global_health_risks Base de dados: MEDLINE Assunto principal: Caenorhabditis elegans Limite: Animals Idioma: En Revista: ACS Nano Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 15_ODS3_global_health_risks Base de dados: MEDLINE Assunto principal: Caenorhabditis elegans Limite: Animals Idioma: En Revista: ACS Nano Ano de publicação: 2024 Tipo de documento: Article