A meta-analysis of the association between RBP4 rs3758539 genotype and metabolic syndrome factors.
Diabetes Obes Metab
; 26(7): 2839-2849, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38637979
ABSTRACT
AIM:
To explore the link between the RBP4 rs3758539 genotype and metabolic syndrome risk factors and whether the impact of this genetic variation displays any potential race discrepancy. MATERIALS ANDMETHODS:
This meta-analysis followed the PRISMA guidelines and was registered with PROSPERO (registration no. CRD42023407999). PubMed, Web of Science, Embase, Cochrane Library, Google Scholar, Airiti Library and CINAHL databases were used for the study search until October 2023. We evaluated the methodological quality using the Joanna Briggs Institute checklist and determined the correlation using a random-effects meta-analysis.RESULTS:
The results indicated that individuals with the rs3758539 GA/AA genotype had a higher risk profile, including lower high-density lipoprotein levels [correlation -0.045, 95% confidence interval (CI) -0.080 to -0.009, p = .015, I2 = 46.9%] and higher body mass index (correlation 0.117, 95% CI 0.036-0.197, p = .005, I2 = 82.0%), body fat (correlation 0.098, 95% CI 0.004-0.191, p = .041, I2 = 64.0%), and low-density lipoprotein levels (correlation 0.074, 95% CI 0.010-0.139, p = .024, I2 = 0%), of developing metabolic syndrome than those with the GG genotype. The subgroup analysis maintained a significantly positive correlation between the rs3758539 GA/AA genotype and body mass index (correlation 0.163, 95% CI 0.031-0.289, p = .016, I2 = 88.9%) but a negative correlation with high-density lipoprotein levels (correlation -0.047, 95% CI -0.087 to -0.006, p = .025, I2 = 65.7%) in the Asian group only.CONCLUSION:
The current meta-analysis supports a significant link between the RBP4 rs3758539 GA/AA genotype and the metabolic syndrome.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome Metabólica
/
Proteínas Plasmáticas de Ligação ao Retinol
/
Genótipo
Limite:
Humans
Idioma:
En
Revista:
Diabetes Obes Metab
Ano de publicação:
2024
Tipo de documento:
Article