Chemical proteomics approaches for protein post-translational modification studies.
Biochim Biophys Acta Proteins Proteom
; 1872(4): 141017, 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38641087
ABSTRACT
The diversity and dynamics of proteins play essential roles in maintaining the basic constructions and functions of cells. The abundance of functional proteins is regulated by the transcription and translation processes, while the alternative splicing enables the same gene to generate distinct protein isoforms of different lengths. Beyond the transcriptional and translational regulations, post-translational modifications (PTMs) are able to further expand the diversity and functional scope of proteins. PTMs have been shown to make significant changes in the surface charges, structures, activation states, and interactome of proteins. Due to the functional complexity, highly dynamic nature, and low presence percentage, the study of protein PTMs remains challenging. Here we summarize and discuss the major chemical biology tools and chemical proteomics approaches to enrich and investigate the protein PTM of interest.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Proteína Pós-Traducional
/
Proteômica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Proteins Proteom
Ano de publicação:
2024
Tipo de documento:
Article