Rhodium-Rhenium Alloy Nanozymes for Non-inflammatory Photothermal Therapy.
ACS Appl Mater Interfaces
; 16(17): 21653-21664, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38644787
ABSTRACT
Analogous to thermal ablation techniques in clinical settings, cell necrosis induced during tumor photothermal therapy (PTT) can provoke an inflammatory response that is detrimental to the treatment of tumors. In this study, we employed a straightforward one-step liquid-phase reduction process to synthesize uniform RhRe nanozymes with an average hydrodynamic size of 41.7 nm for non-inflammatory photothermal therapy. The obtained RhRe nanozymes showed efficient near-infrared (NIR) light absorption for effective PTT, coupled with a remarkable capability to scavenge reactive oxygen species (ROS) for anti-inflammatory treatment. After laser irradiation, the 4T1 tumors were effectively ablated without obvious tumor recurrence within 14 days, along with no obvious increase in pro-inflammatory cytokine levels. Notably, these RhRe nanozymes demonstrated high biocompatibility with normal cells and tissues, both in vitro and in vivo, as evidenced by the lack of significant toxicity in female BALB/c mice treated with 10 mg/kg of RhRe nanozymes over a 14 day period. This research highlights RhRe alloy nanoparticles as bioactive nanozymes for non-inflammatory PTT in tumor therapy.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rênio
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Ródio
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Ligas
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Terapia Fototérmica
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Camundongos Endogâmicos BALB C
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Ano de publicação:
2024
Tipo de documento:
Article