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Human olfactory neurosphere-derived cells: A unified tool for neurological disease modelling and neurotherapeutic applications.
Ansari, Saad; Etekochay, Maudlyn O; Atanasov, Atanas G; Prasad, Vishnu P; Kandimalla, Ramesh; Mofatteh, Mohammad; V, Priyanka; Emran, Talha Bin.
Afiliação
  • Ansari S; Animal Science Department, Faculty of Animal and Agriculture Sciences, Universitas Diponegoro, Semarang, Indonesia.
  • Etekochay MO; Winterset Edge, 4534 Ingham Road, Owings Mills, MD 21117, USA.
  • Atanasov AG; Department of Biotechnology and Nutrigenomics, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, Poland.
  • Prasad VP; Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria.
  • Kandimalla R; Rajiv Gandhi University of Health Sciences, 4th 'T' Block, Jayanagar, Bengaluru - 560 041, Karnataka, India.
  • Mofatteh M; CSIR-Indian Institute of Chemical Technology Uppal Road, Tarnaka, Hyderabad-500007, Telangana State, India.
  • V P; School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
  • Emran TB; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
Int J Surg ; 2024 Apr 23.
Article em En | MEDLINE | ID: mdl-38652180
ABSTRACT
As one of the leading causes of global mortality and morbidity, various neurological diseases cause social and economic burdens. Despite significant advances in the treatment of neurological diseases, establishing a proper disease model, especially for degenerative and infectious diseases, remains a major challenging issue. For long, mice were the model of choice but suffered from serious drawbacks of differences in anatomical and functional aspects of the nervous system. Furthermore, the collection of post-mortem brain tissues limits their usage in cultured cell lines. Overcoming such limitations has prompted the usage of stem cells derived from the peripheral nervous system, such as the cells of the olfactory mucosa as a preferred choice. These cells can be easily cultured in vitro and retain the receptors of neuronal cells life-long. Such cells have various advantages over embryonic or induced stem cells, including homology, and ease of culture and can be conveniently obtained from diseased individuals through either biopsies or exfoliation. They have continuously helped in understanding the genetic and developmental mechanisms of degenerative diseases like Alzheimer's and Parkinson's disease. Moreover, the mode of infection of various viruses that can lead to post-viral olfactory dysfunction, such as the Zika virus can be monitored through these cells in vitro and their therapeutic development can be fastened.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Surg Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Surg Ano de publicação: 2024 Tipo de documento: Article