A robust heterogeneous chiral phosphoric acid enables multi decagram scale production of optically active N,S-ketals.
Green Chem
; 26(8): 4593-4599, 2024 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-38654978
ABSTRACT
Asymmetric organocatalysis has been recognized as one of the "top 10 emerging technologies" in chemistry by IUPAC in 2019. Its potential to make chemical processes more sustainable is promising, but there are still challenges that need to be addressed. Developing new and reliable enantioselective processes for reproducing batch reactions on a large scale requires a combination of chemical and technical solutions. In this manuscript, we combine a robust immobilized chiral phosphoric acid with a new packed-bed reactor design. This combination allows scaling up of the enantioselective addition of thiols to imines from a few milligrams to a multi-decagram scale in a continuous flow process without physical or chemical degradation of the catalyst.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Green Chem
Ano de publicação:
2024
Tipo de documento:
Article