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Cardiorespiratory Fitness as a Predictor of Non-Cardiovascular Disease and Non-Cancer Mortality in Men.
Sparks, Joshua R; Wang, Xuewen; Lavie, Carl J; Zhang, Jiajia; Sui, Xuemei.
Afiliação
  • Sparks JR; Department of Exercise Science, Norman J. Arnold School of Public Health, University of South Carolina, Columbia; Reproductive Endocrinology and Women's Health Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge.
  • Wang X; Department of Exercise Science, Norman J. Arnold School of Public Health, University of South Carolina, Columbia.
  • Lavie CJ; Department of Cardiovascular Disease, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, LA.
  • Zhang J; Department of Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina, Columbia.
  • Sui X; Department of Exercise Science, Norman J. Arnold School of Public Health, University of South Carolina, Columbia. Electronic address: msui@mailbox.sc.edu.
Mayo Clin Proc ; 99(8): 1261-1270, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38661595
ABSTRACT

OBJECTIVE:

To evaluate the association of 5 major cause-specific non-cardiovascular disease (CVD) and non-cancer deaths with cardiorespiratory fitness (CRF).

METHODS:

Patients were 36,645 men (43.3±9.3 years) free of known CVD and cancer at baseline who completed a maximal treadmill graded exercise test during a preventive examination at the Cooper Clinic (Dallas, Texas) between 1971 and 2003. CRF was quantified as maximal treadmill exercise test duration and grouped as low (referent), moderate, and high. Cause-specific non-CVD non-cancer deaths were (1) diabetes or kidney disease, (2) chronic respiratory disease, (3) acute respiratory and infectious disease, (4) injuries, and (5) other non-CVD non-cancer deaths.

RESULTS:

A total of 694 non-CVD non-cancer deaths occurred during an average of 17 years of follow-up. After adjustment for covariates, hazard ratios (95% confidence intervals) for moderate and high CRF, respectively, were 0.57 (0.47 to 0.69) and 0.43 (0.34 to 0.54) for overall non-CVD non-cancer deaths (P<.0001); 0.39 (0.28 to 0.54) and 0.17 (0.10 to 0.28) for diabetes or kidney disease (P<.001); 0.36 (0.22 to 0.59) and 0.09 (0.04 to 0.20) for chronic respiratory diseases (P<.001 for all); 0.74 (0.47 to 1.16) and 0.34 (0.19 to 0.61) for acute respiratory and infectious diseases (P<.01 for both); and 0.48 (0.35 to 0.66) and 0.38 (0.26 to 0.55) for any other non-CVD non-cancer deaths (P<.0001 for both).

CONCLUSION:

Higher levels of CRF were significantly associated with lower risk of mortality from the 5 major non-CVD non-cancer causes. These results suggest that improvement in CRF may reduce non-CVD non-cancer deaths, which account for a significant proportion of adult mortality.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aptidão Cardiorrespiratória Limite: Adult / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Mayo Clin Proc Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aptidão Cardiorrespiratória Limite: Adult / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Mayo Clin Proc Ano de publicação: 2024 Tipo de documento: Article