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Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa.
Haga, Ismar R; Shih, Barbara B; Tore, Gessica; Polo, Noemi; Ribeca, Paolo; Gombo-Ochir, Delgerzul; Shura, Gansukh; Tserenchimed, Tsagaan; Enkhbold, Bazarragchaa; Purevtseren, Dulam; Ulziibat, Gerelmaa; Damdinjav, Batchuluun; Yimer, Lama; Bari, Fufa D; Gizaw, Daniel; Adedeji, Adeyinka Jeremy; Atai, Rebecca Bitiyong; Adole, Jolly Amoche; Dogonyaro, Banenat Bajehson; Kumarawadu, Pradeep Lakpriya; Batten, Carrie; Corla, Amanda; Freimanis, Graham L; Tennakoon, Chandana; Law, Andy; Lycett, Samantha; Downing, Tim; Beard, Philippa M.
Afiliação
  • Haga IR; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
  • Shih BB; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
  • Tore G; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YW, UK.
  • Polo N; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
  • Ribeca P; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
  • Gombo-Ochir D; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
  • Shura G; UK Health Security Agency, 61 Colindale Ave, London NW9 5EQ, UK.
  • Tserenchimed T; NIHR Health Protection Research Unit in Genomics and Enabling Data, Mathematics Institute, Zeeman Builing, University of Warwick, Coventry CV4 7AL, UK.
  • Enkhbold B; NIHR Health Protection Research Unit in Gastrointestinal Infections, Ronald Ross Building, University of Liverpool, Liverpool L69 7BE, UK.
  • Purevtseren D; Biomathematics and Statistics Scotland, James Maxwell Clerk Building, Peter Guthrie Tait Road, Kings Buildings, Edinburgh EH9 3FD, UK.
  • Ulziibat G; Laboratory of Transboundary Animal Disease Diagnosis and Surveillance, State Central Veterinary Laboratory, Zaisan, Ulaanbaatar 17024, Mongolia.
  • Damdinjav B; Laboratory of Transboundary Animal Disease Diagnosis and Surveillance, State Central Veterinary Laboratory, Zaisan, Ulaanbaatar 17024, Mongolia.
  • Yimer L; Laboratory of Transboundary Animal Disease Diagnosis and Surveillance, State Central Veterinary Laboratory, Zaisan, Ulaanbaatar 17024, Mongolia.
  • Bari FD; Laboratory of Transboundary Animal Disease Diagnosis and Surveillance, State Central Veterinary Laboratory, Zaisan, Ulaanbaatar 17024, Mongolia.
  • Gizaw D; Laboratory of Transboundary Animal Disease Diagnosis and Surveillance, State Central Veterinary Laboratory, Zaisan, Ulaanbaatar 17024, Mongolia.
  • Adedeji AJ; Laboratory of Transboundary Animal Disease Diagnosis and Surveillance, State Central Veterinary Laboratory, Zaisan, Ulaanbaatar 17024, Mongolia.
  • Atai RB; General Authority for Veterinary Service, Ministry of Food, Agriculture and Light Industry, Ulaanbaatar 13381, Mongolia.
  • Adole JA; School of Veterinary Medicine, Wollega University, Nekemte P.O. Box 395, Ethiopia.
  • Dogonyaro BB; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 3434, Ethiopia.
  • Kumarawadu PL; College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu P.O. Box 3434, Ethiopia.
  • Batten C; Animal Health Institute (AHI), Sebata P.O. Box 04, Ethiopia.
  • Corla A; National Veterinary Research Institute, Vom 930103, Nigeria.
  • Freimanis GL; National Veterinary Research Institute, Vom 930103, Nigeria.
  • Tennakoon C; National Veterinary Research Institute, Vom 930103, Nigeria.
  • Law A; National Veterinary Research Institute, Vom 930103, Nigeria.
  • Lycett S; Department of Animal Production and Health, Gatambe, Peradeniya 20400, Sri Lanka.
  • Downing T; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
  • Beard PM; The Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.
Viruses ; 16(4)2024 04 03.
Article em En | MEDLINE | ID: mdl-38675899
ABSTRACT
Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have sequenced the whole genome of historical LSDV isolates from the Pirbright Institute virus archive, and field isolates from recent disease outbreaks in Sri Lanka, Mongolia, Nigeria and Ethiopia. These genome sequences were compared to published genomes and classified into different subgroups. Two subgroups contained vaccine or vaccine-like samples ("Neethling-like" clade 1.1 and "Kenya-like" subgroup, clade 1.2.2). One subgroup was associated with outbreaks of LSD in the Middle East/Europe (clade 1.2.1) and a previously unreported subgroup originated from cases of LSD in west and central Africa (clade 1.2.3). Isolates were also identified that contained a mix of genes from both wildtype and vaccine samples (vaccine-like recombinants, grouped in clade 2). Whole genome sequencing and analysis of LSDV strains isolated from different regions of Africa, Europe and Asia have provided new knowledge of the drivers of LSDV emergence, and will inform future disease control strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Genoma Viral / Sequenciamento Completo do Genoma / Doença Nodular Cutânea / Vírus da Doença Nodular Cutânea Limite: Animals País/Região como assunto: Africa Idioma: En Revista: Viruses Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Genoma Viral / Sequenciamento Completo do Genoma / Doença Nodular Cutânea / Vírus da Doença Nodular Cutânea Limite: Animals País/Região como assunto: Africa Idioma: En Revista: Viruses Ano de publicação: 2024 Tipo de documento: Article