Copper-Catalyzed Sulfur Alkylation of Sulfenamides with N-Sulfonylhydrazones.
Org Lett
; 26(18): 3906-3910, 2024 May 10.
Article
em En
| MEDLINE
| ID: mdl-38683227
ABSTRACT
Sulfilimines are valuable compounds in both organic synthesis and pharmaceuticals. In this study, we present a copper-catalyzed sulfur alkylation of sulfenamides with N-sulfonylhydrazones. In contrast to prior findings, hydrazones derived from aldehydes act as donor-type carbene precursors, effectively engaging in coupling with sulfenamides via a copper catalyst, demonstrating exclusive S selectivity. The utility of the protocol was highlighted in the rapid access to a wide range of sulfoximine derivatives.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2024
Tipo de documento:
Article