Stroke risk after transcatheter aortic valve replacement in patients with carotid stenosis: A systematic review and meta-analysis.
Int J Cardiol
; 408: 132085, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38702030
ABSTRACT
BACKGROUND:
Stroke is a feared complication of transcatheter aortic valve replacement (TAVR). Patients undergoing TAVR typically have multiple comorbidities, such as carotid artery stenosis (CAS). We conducted the present meta-analysis to determine the risk of stroke and mortality following TAVR in patients with CAS.METHODS:
We searched PubMed/Medline, Scopus, ScienceDirect, and Cochrane Clinical Trials databases for clinical studies that compared CAS ≥50% and CAS ≥70% versus non-CAS TAVR population. The endpoints included the 30-day incidence of stroke or transient ischemic attack (TIA) and 30-day all-cause of mortality.RESULTS:
We identified seven studies that included 12,418 patients in the CAS group and 102,316 in the control group. CAS ≥50% was not associated with an increased risk of 30-day stroke or TIA after TAVR [risk ratio (RR) 1.38; 95% confidence interval (95% CI) 0.95-2.02; p = 0.09]. However, patients with CAS ≥70% had an increased risk of stroke or TIA (RR 1.43; 95% CI 1.02-2.01; p = 0.04). No difference in 30-day all-cause mortality was observed between CAS ≥50% or CAS ≥70% and control groups (RR 1.09; 95% CI 0.79-1.52; p = 0.59 and RR 1.11; 95% CI 0.85-1.45; p = 0.43, respectively).CONCLUSIONS:
CAS ≥70% was associated with an increased risk of stroke or TIA following TAVR compared with patients without CAS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estenose da Valva Aórtica
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Estenose das Carótidas
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Acidente Vascular Cerebral
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Substituição da Valva Aórtica Transcateter
Limite:
Humans
Idioma:
En
Revista:
Int J Cardiol
Ano de publicação:
2024
Tipo de documento:
Article