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Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants.
van Kuilenburg, André B P; Pleunis-van Empel, Marjolein C H; Brouwer, Rick B; Sijben, Angelique E J; Knapen, Daan G; Oude Munnink, Thijs H; van Zanden, Jelmer J; Janssens-Puister, Jenny; Dobritzsch, Doreen; Meinsma, Rutger; Meijer-Jansen, Judith; van Dooren, Silvy J M; Vijzelaar, Raymon; Pop, Ana; Salomons, Gajja S; Maring, Jan Gerard; Niezen-Koning, Klary E.
Afiliação
  • van Kuilenburg ABP; Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
  • Pleunis-van Empel MCH; Medisch Spectrum Twente, Department of Oncology, Enschede, the Netherlands.
  • Brouwer RB; Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Medlon BV, Enschede, the Netherlands.
  • Sijben AEJ; Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands.
  • Knapen DG; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Oude Munnink TH; Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • van Zanden JJ; Martini Hospital Groningen, Certe Department of Clinical Chemistry, the Netherlands.
  • Janssens-Puister J; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Dobritzsch D; Department of Chemistry, Uppsala University, Biomedical Center, Uppsala, Sweden.
  • Meinsma R; Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
  • Meijer-Jansen J; Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
  • van Dooren SJM; Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
  • Vijzelaar R; MRC-Holland bv, Amsterdam, the Netherlands.
  • Pop A; Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
  • Salomons GS; Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
  • Maring JG; Departments of Clinical Pharmacy and Medical Oncology, Isala, Zwolle, the Netherlands.
  • Niezen-Koning KE; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
JCO Precis Oncol ; 8: e2300599, 2024 May.
Article em En | MEDLINE | ID: mdl-38709992
ABSTRACT
A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Di-Hidrouracila Desidrogenase (NADP) / Deficiência da Di-Hidropirimidina Desidrogenase / Capecitabina / Antimetabólitos Antineoplásicos Limite: Female / Humans / Male / Middle aged Idioma: En Revista: JCO Precis Oncol Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Di-Hidrouracila Desidrogenase (NADP) / Deficiência da Di-Hidropirimidina Desidrogenase / Capecitabina / Antimetabólitos Antineoplásicos Limite: Female / Humans / Male / Middle aged Idioma: En Revista: JCO Precis Oncol Ano de publicação: 2024 Tipo de documento: Article