Neutrophil and macrophage crosstalk might be a potential target for liver regeneration.
FEBS Open Bio
; 14(6): 922-941, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38710666
ABSTRACT
The regenerative capability of the liver is remarkable, but further research is required to understand the role that neutrophils play in this process. In the present study, we reanalyzed single-cell RNA sequencing data from a mouse partial hepatectomy (PH) model to track the transcriptional changes in hepatocytes and non-parenchymal cells. Notably, we unraveled the regenerative capacity of hepatocytes at diverse temporal points after PH, unveiling the contributions of three distinct zones in the liver regeneration process. In addition, we observed that the depletion of neutrophils reduced the survival and liver volume after PH, confirming the important role of neutrophils in liver regeneration. CellChat analysis revealed an intricate crosstalk between neutrophils and macrophages promoting liver regeneration and, using weighted gene correlation network analysis, we identified the most significant genetic module associated with liver regeneration. Our study found that hepatocytes in the periportal zone of the liver are more active than in other zones, suggesting that the crosstalk between neutrophils and macrophages might be a potential target for liver regeneration treatment.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatócitos
/
Hepatectomia
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Regeneração Hepática
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Macrófagos
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Neutrófilos
Limite:
Animals
Idioma:
En
Revista:
FEBS Open Bio
Ano de publicação:
2024
Tipo de documento:
Article