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Inhibitory effect of extracts from edible parts of nuts on α-amylase activity: a systematic review.
Farazi, Mena; Houghton, Michael J; Cardoso, Barbara R; Murray, Margaret; Williamson, Gary.
Afiliação
  • Farazi M; Department of Nutrition, Dietetics and Food, Monash University, BASE Facility, Level 1, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia. michael.houghton@monash.edu.
  • Houghton MJ; Victorian Heart Institute, Monash University, 631 Blackburn Road, Clayton, VIC 3168, Australia.
  • Cardoso BR; Department of Nutrition, Dietetics and Food, Monash University, BASE Facility, Level 1, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia. michael.houghton@monash.edu.
  • Murray M; Victorian Heart Institute, Monash University, 631 Blackburn Road, Clayton, VIC 3168, Australia.
  • Williamson G; Department of Nutrition, Dietetics and Food, Monash University, BASE Facility, Level 1, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia. michael.houghton@monash.edu.
Food Funct ; 15(10): 5209-5223, 2024 May 20.
Article em En | MEDLINE | ID: mdl-38717256
ABSTRACT
Elevated blood glucose concentration is a risk factor for developing metabolic dysfunction and insulin resistance, leading to type 2 diabetes and cardiovascular diseases. Nuts have the potential to inhibit α-amylase activity, and so lower postprandial glucose, due to their content of polyphenols and other bioactive compounds. We conducted a systematic literature review to assess the ability of extracts from commonly consumed edible parts of nuts to inhibit α-amylase. Among the 31 included papers, only four utilised human α-amylases. These papers indicated that polyphenol-rich chestnut skin extracts exhibited strong inhibition of both human salivary and pancreatic α-amylases, and that a polyphenol-rich almond skin extract was a potent inhibitor of human salivary α-amylase. The majority of the reviewed studies utilised porcine pancreatic α-amylase, which has ∼86% sequence homology with the corresponding human enzyme but with some key amino acid variations located within the active site. Polyphenol-rich extracts from chestnut, almond, kola nut, pecan and walnut, and peptides isolated from cashew, inhibited porcine pancreatic α-amylase. Some studies used α-amylases sourced from fungi or bacteria, outcomes from which are entirely irrelevant to human health, as they have no sequence homology with the human enzyme. Given the limited research involving human α-amylases, and the differences in inhibition compared to porcine enzymes and especially enzymes from microorganisms, it is recommended that future in vitro experiments place greater emphasis on utilising enzymes sourced from humans to facilitate a reliable prediction of effects in intervention studies.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Alfa-Amilases / Nozes Limite: Animals / Humans Idioma: En Revista: Food Funct Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Alfa-Amilases / Nozes Limite: Animals / Humans Idioma: En Revista: Food Funct Ano de publicação: 2024 Tipo de documento: Article