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Ferroptosis in renal fibrosis: a mini-review.
Yang, Si-Qi; Zhao, Xi; Zhang, Jing; Liao, Dong-Ying; Wang, Yu-Han; Wang, Yao-Guang.
Afiliação
  • Yang SQ; Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, TianJin, China.
  • Zhao X; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, TianJin, China.
  • Zhang J; Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, TianJin, China.
  • Liao DY; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, TianJin, China.
  • Wang YH; Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, TianJin, China.
  • Wang YG; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, TianJin, China.
J Drug Target ; 32(7): 785-793, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38721679
ABSTRACT
Ferroptosis is a novel form of programmed cell death that is iron-dependent and distinct from autophagy, apoptosis, and necroptosis. It is primarily characterised by a decrease in glutathione peroxidase 4 (GPX4) activity, or by the accumulation of lipid peroxidation and reactive oxygen species (ROS). Renal fibrosis is a common pathological change in the progression of various primary and secondary renal diseases to end-stage renal disease and poses a serious threat to human health with high morbidity and mortality. Multiple pathways contribute to the development of renal fibrosis, with ferroptosis playing a crucial role in renal fibrosis pathogenesis due to its involvement in the production of ROS. Ferroptosis is related to several signalling pathways, including System Xc-/GPX4, abnormal iron metabolism and lipid peroxidation. A number of studies have indicated that ferroptosis is closely involved in the process of renal fibrosis caused by various kidney diseases such as glomerulonephritis, renal ischaemia-reperfusion injury, diabetic nephropathy and renal calculus. Identifying the underlying molecular mechanisms that determine cell death would open up new insights to address a therapeutic strategy to renal fibrosis. The review aimed to browse and summarise the known mechanisms of ferroptosis that may be associated with biological reactions of renal fibrosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose / Ferroptose Limite: Animals / Humans Idioma: En Revista: J Drug Target Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose / Ferroptose Limite: Animals / Humans Idioma: En Revista: J Drug Target Ano de publicação: 2024 Tipo de documento: Article