PM2.5 regulates the progression of lung adenocarcinoma through the axis of HCG18, miR-195 and ATG14.
Clin Exp Pharmacol Physiol
; 51(6): e13861, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38724488
ABSTRACT
Relevant studies have indicated the association of HCG18 with tumour occurrence and progression. In this study, we observed that PM2.5 can enhance the growth of lung adenocarcinoma cells by modulating the expression of HCG18. Further investigations, including overexpression and knockout experiments, elucidated that HCG18 suppresses miR-195, which in turn upregulates the expression of ATG14, resulting in the upregulation of autophagy. Consequently, exposure to PM2.5 leads to elevated HCG18 expression in lung tissues, which in turn increases Atg14 expression and activates autophagy pathways through inhibition of miR-195, thereby contributing to oncogenesis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Progressão da Doença
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MicroRNAs
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Material Particulado
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Proteínas Relacionadas à Autofagia
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Adenocarcinoma de Pulmão
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Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Ano de publicação:
2024
Tipo de documento:
Article