Analgesic and Psychotropic Effects of a New Bradykinin Antagonist.
Bull Exp Biol Med
; 176(5): 581-584, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38724817
ABSTRACT
A bradykinin B1 receptors antagonist PAV-0056, an 1,4-benzodiazepin-2-one derivative, intragastrically administrated to mice at doses of 0.1 and 1 mg/kg causes analgesia in the "formalin test" not inferior to that of diclofenac sodium (10 mg/kg) and tramadol (20 mg/kg). PAV-0056 at doses of 0.1 and 10 mg/kg has no anxiolytic and central muscle relaxant effects in mice and does not damage the gastric mucosa in rats. Based on the results of the conditioned place preference test, PAV-0056 also does not induce addiction in mice.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Analgésicos
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2024
Tipo de documento:
Article