Polycyclic aromatic hydrocarbons exposure and arterial stiffness-related plasma miRNAs: A panel study.
Environ Toxicol Pharmacol
; 108: 104464, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38729543
ABSTRACT
The underlying mechanisms between polycyclic aromatic hydrocarbons (PAHs) exposure and arterial stiffness are poorly understood. We carried out a panel study involving three repeated surveys to examine the associations of individual and mixture of PAHs exposure with arterial stiffness-related miRNAs among 123 community adults. In linear mixed-effect (LME) models, we found that urinary 9-hydroxyfluorene (9-OHFlu), 2-hydroxyphenanthrene (2-OHPh), 9-hydroxyphenanthrene (9-OHPh) at lag 0â¯day were positively linked to miR-146a and/or miR-222. The Bayesian kernel machine regression (BKMR) analyses revealed positive overall associations of PAHs mixture at lag 0â¯day with miR-146a and miR-222, and urinary 9-OHFlu contributed the most. In addition, an inter-quartile range (IQR) increase in urinary 9-OHFlu at lag 0â¯day was associated with elevated miR-146a and miR-222 by 0.16 (95% CI 0.02, 0.30) to 0.34 (95% CI 0.13, 0.54). Accordingly, exposure to PAHs, especially 9-OHFlu at lag 0â¯day, was related to elevated arterial stiffness-related plasma miRNAs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocarbonetos Policíclicos Aromáticos
/
MicroRNAs
/
Rigidez Vascular
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Ano de publicação:
2024
Tipo de documento:
Article