Choroid plexus enlargement is associated with future periventricular neurodegeneration in multiple sclerosis.
Mult Scler Relat Disord
; 87: 105668, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38744032
ABSTRACT
BACKGROUND:
The choroid plexus (CP), located within the ventricles of the brain and the primary producer of cerebrospinal fluid, has been shown to be enlarged in patients with multiple sclerosis (MS) and linked to periventricular remyelination failure. Atrophied T2-lesion volume (aT2-LV), a promising neurodegenerative imaging marker in progressive MS (PMS), reflects the volume of periventricular lesions subsumed into cerebrospinal fluid over the follow-up.METHODS:
In a cohort of 143 people with relapsing-remitting MS (RRMS) and 53 with PMS, we used 3T magnetic resonance imaging (MRI) to quantify CP volume (CPV) at baseline and aT2-LV over an average of 5.4 years of follow-up. Partial correlations, adjusting for age and sex, and linear regression analyses were used to assess the relationships between imaging measures.RESULTS:
In both cohorts, CPV was associated with aT2-LV in both the RRMS group (r = 0.329, p < 0.001) as well as the PMS group (r = 0.522, p < 0.001). In regression analyses predicting aT2-LV, ventricular volume (final adjusted R2 = 0.407, p < 0.001) explained additional variance beyond age, sex, and T2-lesion volume in the RRMS group while CPV (final adjusted R2 = 0.446, p = 0.009) was retained in the PMS group.CONCLUSION:
Findings from this study suggest that the CP enlargement is associated with future neurodegeneration, with a particularly relevant role in PMS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Ventrículos Cerebrais
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Plexo Corióideo
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Esclerose Múltipla Crônica Progressiva
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Esclerose Múltipla Recidivante-Remitente
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mult Scler Relat Disord
Ano de publicação:
2024
Tipo de documento:
Article