Pubertal Suppression in Early Puberty Followed by Testosterone Mildly Increases Final Height in Transmasculine Youth.
J Endocr Soc
; 8(6): bvae089, 2024 Apr 06.
Article
em En
| MEDLINE
| ID: mdl-38752206
ABSTRACT
Context Treatment for transmasculine youth (TMY) can involve testosterone treatment and is sometimes preceded by gonadotropin-releasing hormone agonist (GnRHa) treatment for puberty blockade. GnRHas can increase final height in birth-assigned females with central precocious puberty. Maximizing final adult height (FAH) is an important outcome for many TMY. Objective:
Our objective was to determine how GnRHa treatment before testosterone impacts FAH.Methods:
Retrospective cohort study at 5 US transgender health clinics. Participants were 32 TMY treated with GnRHas in early to midpuberty before testosterone (GnRHa + T group) and 62 late/postpubertal TMY treated with testosterone only (T-only group).Results:
The difference between FAH minus midparental target height (MPTH) was +2.3 ± 5.7â cm and -2.2 ± 5.6â cm in the GnRHa + T and T-only groups, respectively (P < .01). In the GnRHa + T group, FAH was 1.8 ± 3.4â cm greater than predicted adult height (PAH) (P < .05) and FAH vs initial height (IH) z-score was 0.5 ± 1.2 vs 0.16 ± 1.0 (P < .05). After adjusting for patient characteristics, each additional month of GnRHa monotherapy increased FAH by 0.59â cm (95% CI 0.31, 0.9â cm), stage 3 breast development at start of GnRHa was associated with 6.5â cm lower FAH compared with stage 2 (95% CI -10.43, -2.55), and FAH was 7.95â cm greater in the GnRHa + T group than in T-only group (95% CI -10.85, -5.06).Conclusion:
Treatment with GnRHa in TMY in early puberty before testosterone increases FAH compared with MPTH, PAH, IH, and TMY who only received testosterone in late/postpuberty. TMY considering GnRHas should be counseled that GnRHas may mildly increase their FAH if started early.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Endocr Soc
Ano de publicação:
2024
Tipo de documento:
Article