Degradation of muramyl dipeptide by mammalian serum.
Infect Immun
; 50(1): 320-1, 1985 Oct.
Article
em En
| MEDLINE
| ID: mdl-3876287
ABSTRACT
Muramyl dipeptide, N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), is the minimal biologically active subunit of bacterial peptidoglycan and elicits an acute inflammation in vivo. We now report that MDP is degraded by normal rat serum into its constituents, N-acetylmuramic acid and L-alanine-D- isoglutamine. The dipeptide is further degraded into its components L-alanine and D-isoglutamine. These results may help to explain how inflammation elicited by MDP is terminated in vivo.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilmuramil-Alanil-Isoglutamina
Limite:
Animals
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
1985
Tipo de documento:
Article