COVID-19 therapeutics.
Clin Microbiol Rev
; 37(2): e0011923, 2024 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-38771027
ABSTRACT
SUMMARYSince the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options has been studied and deployed. Healthcare providers have multiple treatment approaches to choose from, but efficacy of those approaches often remains controversial or compromised by viral evolution. Uncertainties still persist regarding the best therapies for high-risk patients, and the drug pipeline is suffering fatigue and shortage of funding. In this article, we review the antiviral activity, mechanism of action, pharmacokinetics, and safety of COVID-19 antiviral therapies. Additionally, we summarize the evidence from randomized controlled trials on efficacy and safety of the various COVID-19 antivirals and discuss unmet needs which should be addressed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
SARS-CoV-2
/
COVID-19
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Tratamento Farmacológico da COVID-19
Limite:
Humans
Idioma:
En
Revista:
Clin Microbiol Rev
Ano de publicação:
2024
Tipo de documento:
Article