Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning.
Nat Commun
; 15(1): 4100, 2024 May 21.
Article
em En
| MEDLINE
| ID: mdl-38773091
ABSTRACT
In most models of neuronal plasticity and memory, dopamine is thought to promote the long-term maintenance of Long-Term Potentiation (LTP) underlying memory processes, but not the initiation of plasticity or new information storage. Here, we used optogenetic manipulation of midbrain dopamine neurons in male DATCre mice, and discovered that stimulating the Schaffer collaterals - the glutamatergic axons connecting CA3 and CA1 regions - of the dorsal hippocampus concomitantly with midbrain dopamine terminals within a 200 millisecond time-window triggers LTP at glutamatergic synapses. Moreover, we showed that the stimulation of this dopaminergic pathway facilitates contextual learning in awake behaving mice, while its inhibition hinders it. Thus, activation of midbrain dopamine can operate as a teaching signal that triggers NeoHebbian LTP and promotes supervised learning.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dopamina
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Área Tegmentar Ventral
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Potenciação de Longa Duração
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Neurônios Dopaminérgicos
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Optogenética
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Hipocampo
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Aprendizagem
Limite:
Animals
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2024
Tipo de documento:
Article