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Exosome is a Fancy Mobile Sower of Ferroptosis.
Hou, Qin; Ouyang, Siyu; Xie, Zhongcheng; He, Yinling; Deng, Yunong; Guo, Jiamin; Yu, Panpan; Tan, Xiaoqian; Ma, Wentao; Li, Pin; Yu, Jiang; Mo, Qinger; Zhang, Zhixia; Chen, Dandan; Lin, Xiaoyan; Liu, Zhiyang; Chen, Xi; Peng, Tianhong; Li, Liang; Xie, Wei.
Afiliação
  • Hou Q; Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Ouyang S; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Xie Z; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • He Y; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Deng Y; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Guo J; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Yu P; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Tan X; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Ma W; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Li P; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Yu J; Class of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Mo Q; Class of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Zhang Z; Class of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Chen D; Class of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Lin X; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Liu Z; Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Chen X; Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Peng T; Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. thpeng67@163.com.
  • Li L; Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. 26002860@qq.com.
  • Xie W; Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. weixiehy@126.com.
J Cardiovasc Transl Res ; 2024 May 22.
Article em En | MEDLINE | ID: mdl-38776048
ABSTRACT
Exosomes, nano-sized small extracellular vesicles, have been shown to serve as mediators between intercellular communications by transferring bioactive molecules, such as non-coding RNA, proteins, and lipids from secretory to recipient cells, modulating a variety of physiological and pathophysiological processes. Recent studies have gradually demonstrated that altered exosome charges may represent a key mechanism driving the pathological process of ferroptosis. This review summarizes the potential mechanisms and signal pathways relevant to ferroptosis and then discusses the roles of exosome in ferroptosis. As well as transporting iron, exosomes may also indirectly convey factors related to ferroptosis. Furthermore, ferroptosis may be transmitted to adjacent cells through exosomes, resulting in cascading effects. It is expected that further research on exosomes will be conducted to explore their potential in ferroptosis and will lead to the creation of new therapeutic avenues for clinical diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cardiovasc Transl Res Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cardiovasc Transl Res Ano de publicação: 2024 Tipo de documento: Article