Machine learning-based preoperative analytics for the prediction of anastomotic leakage in colorectal surgery: a swiss pilot study.
Surg Endosc
; 38(7): 3672-3683, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38777894
ABSTRACT
BACKGROUND:
Anastomotic leakage (AL), a severe complication following colorectal surgery, arises from defects at the anastomosis site. This study evaluates the feasibility of predicting AL using machine learning (ML) algorithms based on preoperative data.METHODS:
We retrospectively analyzed data including 21 predictors from patients undergoing colorectal surgery with bowel anastomosis at four Swiss hospitals. Several ML algorithms were applied for binary classification into AL or non-AL groups, utilizing a five-fold cross-validation strategy with a 90% training and 10% validation split. Additionally, a holdout test set from an external hospital was employed to assess the models' robustness in external validation.RESULTS:
Among 1244 patients, 112 (9.0%) suffered from AL. The Random Forest model showed an AUC-ROC of 0.78 (SD ± 0.01) on the internal test set, which significantly decreased to 0.60 (SD ± 0.05) on the external holdout test set comprising 198 patients, including 7 (3.5%) with AL. Conversely, the Logistic Regression model demonstrated more consistent AUC-ROC values of 0.69 (SD ± 0.01) on the internal set and 0.61 (SD ± 0.05) on the external set. Accuracy measures for Random Forest were 0.82 (SD ± 0.04) internally and 0.87 (SD ± 0.08) externally, while Logistic Regression achieved accuracies of 0.81 (SD ± 0.10) and 0.88 (SD ± 0.15). F1 Scores for Random Forest moved from 0.58 (SD ± 0.03) internally to 0.51 (SD ± 0.03) externally, with Logistic Regression maintaining more stable scores of 0.53 (SD ± 0.04) and 0.51 (SD ± 0.02).CONCLUSION:
In this pilot study, we evaluated ML-based prediction models for AL post-colorectal surgery and identified ten patient-related risk factors associated with AL. Highlighting the need for multicenter data, external validation, and larger sample sizes, our findings emphasize the potential of ML in enhancing surgical outcomes and inform future development of a web-based application for broader clinical use.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fístula Anastomótica
/
Aprendizado de Máquina
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Surg Endosc
Ano de publicação:
2024
Tipo de documento:
Article