Estimating RNA Secondary Structure Folding Free Energy Changes with efn2.
Methods Mol Biol
; 2726: 1-13, 2024.
Article
em En
| MEDLINE
| ID: mdl-38780725
ABSTRACT
A number of analyses require estimates of the folding free energy changes of specific RNA secondary structures. These predictions are often based on a set of nearest neighbor parameters that models the folding stability of a RNA secondary structure as the sum of folding stabilities of the structural elements that comprise the secondary structure. In the software suite RNAstructure, the free energy change calculation is implemented in the program efn2. The efn2 program estimates the folding free energy change and the experimental uncertainty in the folding free energy change. It can be run through the graphical user interface for RNAstructure, from the command line, or a web server. This chapter provides detailed protocols for using efn2.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Termodinâmica
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Software
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RNA
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Dobramento de RNA
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Conformação de Ácido Nucleico
Idioma:
En
Revista:
Methods Mol Biol
Ano de publicação:
2024
Tipo de documento:
Article