Regiodivergent Remote C-H Functionalization by Tuning Template Geometry.
Org Lett
; 26(22): 4733-4737, 2024 Jun 07.
Article
em En
| MEDLINE
| ID: mdl-38780902
ABSTRACT
For transition-metal-catalyzed C-H functionalization, precise differentiation between remote adjacent C(sp2)-H bonds remains a long-standing challenge. Here, the template structure-directivity relationship on remote C-H functionalization of arenes was experimentally and computationally studied. By using geometry-tunable templates, Pd-catalyzed remote meta- and para-C-H activation of benzoic acids was achieved with high site selectivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2024
Tipo de documento:
Article