Flicker electroretinogram in preterm infants.
Eye (Lond)
; 38(14): 2768-2774, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-38783086
ABSTRACT
BACKGROUND:
Infants born prematurely are at risk of developing retinopathy of prematurity, which is associated with abnormalities in retinal function as measured using electroretinography. The aim of this study was to record non-invasive flicker electroretinograms (ERGs) in preterm infants and compare function of moderate and very or extremely preterm infants.METHODS:
In this non-randomized, cross-sectional study, 40 moderate preterm (gestational age (GA) 34 0/7 to 36 6/7 weeks, Group A) and 40 very or extremely preterm infants (GA ≤ 31 weeks, Group B) were recruited for flicker ERG recording through closed eyelids using the RETeval® device and skin electrodes. Group A was tested within the first week of life and Group B between 34th and 37th week postmenstrual age. Flicker stimuli were presented at 28.3 Hz with stimulus levels of 3, 6, 12, 30 and 50 cdâ¢s/m2. Primary endpoints were peak time (ms) and amplitude (µV).RESULTS:
Flicker ERGs were recordable in most infants with the highest proportion of reproducible ERGs at 30 cdâ¢s/m2. Amplitudes increased with stronger flicker stimulation, while peak times did not differ significantly between stimulus levels nor groups. Amplitudes were significantly greater in Group B at the strongest stimulus level (Mann-Whitney-U-Test=198.00, Z = 4.097, p = <0.001).CONCLUSIONS:
Feasibility of collecting flicker ERG data in most preterm infants was confirmed. We found no evidence of reduced retinal responses to flicker stimuli associated with extreme prematurity. Higher amplitudes in very and extremely preterm infants could indicate acceleration of retinal development following birth, triggered by visual stimulation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
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Retinopatia da Prematuridade
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Recém-Nascido Prematuro
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Idade Gestacional
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Eletrorretinografia
Limite:
Female
/
Humans
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Male
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Newborn
Idioma:
En
Revista:
Eye (Lond)
Ano de publicação:
2024
Tipo de documento:
Article