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Neural correlates of obesity across the lifespan.
Morys, Filip; Tremblay, Christina; Rahayel, Shady; Hansen, Justine Y; Dai, Alyssa; Misic, Bratislav; Dagher, Alain.
Afiliação
  • Morys F; Montreal Neurological Institute, McGill University, H3A 2B4, Montreal, QC, Canada. filip.morys@mcgill.ca.
  • Tremblay C; Montreal Neurological Institute, McGill University, H3A 2B4, Montreal, QC, Canada.
  • Rahayel S; Department of Medicine and Medical Specialties, University of Montreal, Montreal, QC, Canada.
  • Hansen JY; Center for Advanced Research in Sleep Medicine, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada.
  • Dai A; Montreal Neurological Institute, McGill University, H3A 2B4, Montreal, QC, Canada.
  • Misic B; Montreal Neurological Institute, McGill University, H3A 2B4, Montreal, QC, Canada.
  • Dagher A; Montreal Neurological Institute, McGill University, H3A 2B4, Montreal, QC, Canada.
Commun Biol ; 7(1): 656, 2024 May 28.
Article em En | MEDLINE | ID: mdl-38806652
ABSTRACT
Associations between brain and obesity are bidirectional changes in brain structure and function underpin over-eating, while chronic adiposity leads to brain atrophy. Investigating brain-obesity interactions across the lifespan can help better understand these relationships. This study explores the interaction between obesity and cortical morphometry in children, young adults, adults, and older adults. We also investigate the genetic, neurochemical, and cognitive correlates of the brain-obesity associations. Our findings reveal a pattern of lower cortical thickness in fronto-temporal brain regions associated with obesity across all age cohorts and varying age-dependent patterns in the remaining brain regions. In adults and older adults, obesity correlates with neurochemical changes and expression of inflammatory and mitochondrial genes. In children and older adults, adiposity is associated with modifications in brain regions involved in emotional and attentional processes. Thus, obesity might originate from cognitive changes during early adolescence, leading to neurodegeneration in later life through mitochondrial and inflammatory mechanisms.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Obesidade Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Commun Biol Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Obesidade Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Commun Biol Ano de publicação: 2024 Tipo de documento: Article