Plasmodium falciparum infection in humans and mosquitoes influence natural Anopheline biting behavior and transmission.
Nat Commun
; 15(1): 4626, 2024 May 30.
Article
em En
| MEDLINE
| ID: mdl-38816383
ABSTRACT
The human infectious reservoir of Plasmodium falciparum is governed by transmission efficiency during vector-human contact and mosquito biting preferences. Understanding biting bias in a natural setting can help target interventions to interrupt transmission. In a 15-month cohort in western Kenya, we detected P. falciparum in indoor-resting Anopheles and human blood samples by qPCR and matched mosquito bloodmeals to cohort participants using short-tandem repeat genotyping. Using risk factor analyses and discrete choice models, we assessed mosquito biting behavior with respect to parasite transmission. Biting was highly unequal; 20% of people received 86% of bites. Biting rates were higher on males (biting rate ratio (BRR) 1.68; CI 1.28-2.19), children 5-15 years (BRR 1.49; CI 1.13-1.98), and P. falciparum-infected individuals (BRR 1.25; CI 1.01-1.55). In aggregate, P. falciparum-infected school-age (5-15 years) boys accounted for 50% of bites potentially leading to onward transmission and had an entomological inoculation rate 6.4x higher than any other group. Additionally, infectious mosquitoes were nearly 3x more likely than non-infectious mosquitoes to bite P. falciparum-infected individuals (relative risk ratio 2.76, 95% CI 1.65-4.61). Thus, persistent P. falciparum transmission was characterized by disproportionate onward transmission from school-age boys and by the preference of infected mosquitoes to feed upon infected people.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
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Malária Falciparum
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Mosquitos Vetores
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Mordeduras e Picadas de Insetos
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Anopheles
Limite:
Adolescent
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Adult
/
Animals
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2024
Tipo de documento:
Article